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ea0044p23 | Adrenal and Steroids | SFEBES2016

The pharmacokinetic profile of prednisolone is not affected by ingestion of food – how should patients be advised?

Choudhury Sirazum M , Williams Emma L , Tan Tricia M , Meeran Karim

Background: Prednisolone is used for glucocorticoid replacement therapy in Adrenal Insufficiency. Package inserts indicate that prednisolone should be administered with or after food as there is a belief that prednisolone causes stomach ulcers. We have investigated the impact of various fasted and non-fasted states on its pharmacokinetic profile.Method: A healthy volunteer provided three 4 mg prednisolone profiles. The first was a fasted reference curve....

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ea0044p26 | Adrenal and Steroids | SFEBES2016

Could modified release prednisone hold the key to closer reproduction of the glucocorticoid circadian rhythm in Adrenal Insufficiency?

Choudhury Sirazum M , Leckey Adam , Williams Emma L , Tan Tricia M , Meeran Karim

Background: The cortisol circadian rhythm has an early morning peak with an increase before awakening, and a second lunchtime peak. Using a UPLC-MS/MS technique to measure prednisolone, the active metabolite of prednisone, we investigated the suitability of modified release (MR) prednisone (Lodotra) as a replacement therapy.Method: Blood samples were taken at fixed time points after the administration of MR-prednisone. Concentrations of the active metabo...

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Endocrine Abstracts

The pharmacokinetic profile of prednisolone is not affected by ingestion of food – how should patients be advised?

Could modified release prednisone hold the key to closer reproduction of the glucocorticoid circadian rhythm in Adrenal Insufficiency?

BiosciAbstracts